The Lady Panthers face off against Mobile Christian in their Round 1 game. This game will be live streamed on the Panther Sports Network.
| Winners’ Bracket: Round 1 | ||||||
| # | Home | Away | Date | Time | Venue | |
| 1 | Mobile Christian (Mobile) | Geneva (Geneva) | 05/11/18 | 12:00 PM CDT | Gulf Shores Sportsplex | |
| 2 | T.R. Miller (Brewton) | Wicksburg (Newton) | 05/11/18 | 12:00 PM CDT | Gulf Shores Sportsplex | |
| 3 | Providence Christian (Dothan) | Excel (Excel) | 05/11/18 | 12:00 PM CDT | Gulf Shores Sportsplex | |
| 4 | Opp (Opp) | Clarke County (Grove Hill) | 05/11/18 | 12:00 PM CDT | Gulf Shores Sportsplex | |